Alexey Sergushichev

Alexey Sergushichev

Research Groups


Alexey leads bioinformatics group at joint ITMO University & JetBrains Research laboratory. He graduated from ITMO University in 2013 and received Master degree with honors in Computer Science. There he also defended his PhD under supervision of Maxim Artyomov. His work is dedicated to developing algorithms for computational biology problems, in particular for analysis of metabolic networks.



LKB1 expressed in dendritic cells governs the development and expansion of thymus-derived regulatory T cells

April 2019

Leonard R. Pelgrom, Thiago A. Patente, Alexey Sergushichev, Ekaterina Esaulova, Frank Otto, Arifa Ozir-Fazalalikhan, Hendrik J. P. van der Zande, Alwin J. van der Ham, Stefan van der Stel, Maxim N. Artyomov & Bart Everts

Cell Research, volume 29, pages 406–419

Read more

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

April 2018

Monika Bambouskova, Laurent Gorvel, Vicky Lampropoulou, Alexey Sergushichev, Ekaterina Loginicheva, Kendall Johnson, Daniel Korenfeld, Mary Elizabeth Mathyer, Hyeryun Kim, Li-Hao Huang, Dustin Duncan, Howard Bregman, Abdurrahman Keskin, Andrea Santeford, Rajendra S. Apte, Raghav Sehgal, Britney Johnson, Gaya K. Amarasinghe, Miguel P. Soares, Takashi Satoh, Shizuo Akira, Tsonwin Hai, Cristina de Guzman Strong, Karine Auclair, Thomas P. Roddy, Scott A. Biller, Marko Jovanovic, Eynav Klechevsky, Kelly M. Stewart, Gwendalyn J. Randolph & Maxim N. Artyomov


Read more

Draft Genome Sequence of Coxiella burnetii Historical Strain Leningrad-2, Isolated from Blood of a Patient with Acute Q Fever in Saint Petersburg, Russia

January 2018

Olga Freylikhman, Artem Kiselev, Sergey Kazakov, Alexey Sergushichev, Yulia Panferova, Nikolay Tokarevich, Anna Kostareva

Genome Announc vol. 6 no. 3 e01464-17

Read more

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease

August 2017

Tyler K. Ulland, Wilbur M. Song, Stanley Ching-Cheng Huang, Jason D. Ulrich, Alexey Sergushichev, Wandy L. Beatty, Alexander A. Loboda, Yingyue Zhou, Nigel J. Cairns, Amal Kambal, Ekaterina Loginicheva, Susan Gilfillan, Marina Cella, Herbert W. Virgin, Emil R. Unanue, Yaming Wang, Maxim N. Artyomov, David M. Holtzman, Marco Colonna

Cell, Volume 170, Issue 4

Read more

Ranking Vertices for Active Module Recovery Problem

April 2017

Javlon E. Isomurodov, Alexander A. Loboda, Alexey A. Sergushichev

Algorithms for Computational Biology

Read more

Integrating immunometabolism and macrophage diversity

October 2016

Maxim N. Artyomov, Alexey Sergushichev, Joel D. Schilling

Seminars in Immunology, Volume 28, Issue 5

Read more

Solving Generalized Maximum-Weight Connected Subgraph Problem for Network Enrichment Analysis

August 2016

Alexander A. Loboda, Maxim N. Artyomov, Alexey A. Sergushichev

Read more

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

July 2016

V. Lampropoulou, A. Sergushichev, M. Bambouskova, S. Nair, E. Vincent, E. Loginicheva, L. Cervantes-Barragan, X. Ma, S. Huang, T. Griss, C. Weinheimer, S. Khader, G. Randolph, E. Pearce, R. G. Jones, A. Diwan, M. Diamond,M. N. Artyomov

Cell Metabolism

Read more

GAM: a web-service for integrated transcriptional and metabolic network analysis

April 2016

Alexey A. Sergushichev, Alexander A. Loboda, Abhishek K. Jha, Emma E. Vincent, Edward M. Driggers, Russell G. Jones, Edward J. Pearce and Maxim N. Artyomov

Nucleic Acids Research, Vol. 44

Read more

Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth

October 2015

E. Vincent, A. Sergushichev, T. Griss, M. Gingras, B. Samborska, T. Ntimbane, P. Coelho, J. Blagih, T. Raissi, L. Choinière, G. Bridon, E. Loginicheva, B. Flynn, E. Thomas, J. Tavaré, D. Avizonis, A. Pause, D. Elder, M. Artyomov, R. Jones

Molecular Cell, Vol. 60, Issue 2, p195–207

Read more

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

March 2015

Abhishek K. Jha, Stanley Ching-Cheng Huang, Alexey Sergushichev, Vicky Lampropoulou, Yulia Ivanova, Ekaterina Loginicheva, Karina Chmielewski, Kelly M. Stewart, Juliet Ashall, Bart Everts, Edward J. Pearce, Edward M. Driggers, and Maxim N. Artyomov

Immunity. - Vol. 42, No. 3. - P. 419-430.

Read more